Cell culture products

We meet emerging market needs by developing products based on our core cell culture medium and culture bag technologies.

FUKOKU has been manufacturing cell culture bag products since 2003. Products with superior safety and quality are required for use as the cell culture containers used during the cell culture process in cell therapy.
We continued to develop unique products in desire to bring closed systems to the cell culture process. In addition to cell culture bags, we also provide products such as cell culture media, cell culture systems, and stem cell conditioned media.
All of these products are produced in class 1000 or class 10000 cleanroom environments.

Cell culture bags

Cell culture media

Stem cell conditioned media

Cell culture bags

Developed for immune cell therapy research, the bags are also ideal for use as culture containers for lymphocytes and other floating cells. They are made from highly gas-permeable film for high-density cultures. The highly transparent film also allows for microscopic observation.
Closed system bags can be used to reduce the risk of contamination or infection by foreign substances, bacteria, and viruses.
They are made from material compliant with the Japanese Pharmacopoeia plastic medical and pharmaceutical product container testing methodology, as well as sterilized transfusion set standards.
We can also customize the shapes, tubes, and ports of single-use bags (gas barrier properties).
We also develop cell cryopreservation bags that offer superior anti-shock performance in extremely low temperatures (-196°C). Please contact us for details.

Cell culture bag product lineup

Product		FKCB-ST3	FKCB215	FKCB-215C anti-CD3 antibody (coat bag)
Shape
Culture area	Length Width Volume	292mm 220mm 〜1200ml	183mm 120mm 〜350ml	183mm 120mm 〜350ml
Tubes		Filling tube Sampling tube Connection tube	Filling tube Sampling tube	Filling tube Sampling tube
Suggested retail price/bag		Please contact us
Quantity per box		10	10	10

*Larger cultures can be grown by connecting FKCB 215 and FKCB-ST3.

Cell culture media

FUKOKU develops and manufactures a range of cell culture media, and provides products with superior proliferative response suited to the type of cell and application.
We can provide filled cell culture bags for use in suspension cell culture applications. A closed cell culture can help reduce the risk of contamination or infection by foreign substances, bacteria, or viruses. We can also substitute the material for one with gas barrier properties for single-use bag applications, change the tube diameter/length, or customize port specifications (for example, changing the product from a needle-type product to a needleless product).

FKCM 101
Liquid culture medium for human T cell activation and expansion

Use: Used for human peripheral blood lymphocyte activation cultures.

• Includes no proteins other than human serum albumin
• Includes streptomycin as an antibiotic
• Adding 4% serum during primary culturing can promote cell proliferation
• Culture can grow without serum during expansion culturing
• Bags are made from materials with superior gas permeability, and their safety and quality complies with the method for plastic containers of the JAPAN pharmacopoeia.
• Regenerative medicine, etc. product material eligibility confirmed (Medical Device Inspection Office Notice No. 1122004)

Product lineup	IL-2 content	Volume
FKCM 101T	No IL-2	1000ml
FKCM 101B	No IL-2	1000ml
FKCM101-L300T	IL-2 300 IU/ml	1000ml
FKCM101-L300BA	IL-2 300 IU/ml	1000ml
FKCM101-L13T	IL-2 1300 IU/ml	1000ml

*MF registered (No. 230MF40005)

FKCM 201
Serum-free medium for human fibroblasts

Use: Contains components required for human fibroblasts to proliferate and maintain functionality, for use in researching wound healing, skin conditions, etc.

• Medium materials contain no animal by-products
• Includes streptomycin as an antibiotic
• No need to add cell-adhesion factors such as collagen during primary culturing
• Adding 0.5% to 2% serum can promote cell proliferation

Product lineup	Volume	Packaging
FKCM 201T	500ml	Plastic bottle

FKCM 301
Serum-free medium for human mesenchymal stem cells

Use: Contains components required for mesenchymal stem cells to proliferate and maintain functionality, for use in researching regenerative medicine, immunological conditions, etc.

• Medium materials contain no animal by-products
• Includes streptomycin as an antibiotic
• No need to add cell-adhesion factors such as collagen during primary culturing
• Adding 0.5% to 2% serum can promote cell proliferation

Product lineup	Volume	Packaging
FKCM 301T	500ml	Plastic bottle

Cell culture supernatant fluid

In September 2020, we began manufacturing stem cell conditioned media and exosomes using original liquid media developed based on our liquid media evaluation technology.
conditioned media is a fluid that contains various proteins produced by cells during cell culturing. It contains abundant cell activation messengers called GFs (growth factors) and has gained recent attention for its use as an ingredient in aging care cosmetics.
In compliance with standards for cosmetics ingredients, FUKOKU uses culture media developed in-house to maximize cell proliferation in order to develop products that use supernatant produced by culturing cells in a manner that has been confirmed to be safe. These products are “human fat-derived stem cell acclimated culture solution” and “human fat interstitial cell exosomes.”

Human Adipose Derived Stem Cell Conditioned Media

Growth factors contained in acclimated culture solution (actual measurements, unit: pg/ml)
VEGF　3,500　HGF　6,220　EGF　5,900
TGF-β1　2,Hyaluronic acid ,000

Human Adipose Stromal Cell Exosomes

Exosomes are extracellular vesicles roughly 50 nm to 150 nm in size that are secreted from cells. They continue to attract attention in the regenerative medicine field due to the important role they play in transmitting information between cells. FUKOKU exosomes used in cosmetics have been verified to have a count of 50 billion per milliliter every one milliliter of suspension liquid, via exosome quantitative analysis using the ELISA method.

Negative virus tests

Cultured human adipose derived stem cells have been verified not to include the following viruses, including biological ingredient standard items.

Why people choose FUKOKU’s cell culture-related products

01Clean manufacturing environment

All of our cell culture-related products are produced in class 1000 or class 10000 cleanroom environments.

02One-stop support

We can provide one-stop support for our media and other products, by shipping containers (bottles, bags, etc.) already filled.

Products filled in containers

03Approved for life science business activities; excellent quality management system; compliant with laws, regulations, and standards

• Category II medical device manufacturing/sales permit number: 10B2X10011
• Medical device manufacturing permit registration number: 10BZ200093
• Drug substance, etc. registry (liquid media)*
• Regenerative medicine, etc. product material compliance consultation*
• Guidelines on requirements for process materials specialized for cell processing
• Forum for Innovative Regenerative Medicine Equipment Users Guide, etc.
  *Please contact us for information on products that have been registered or for which compliance has been verified

Download materials on cell culture-related products

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We provide a range of products including motors and bacteria testing kits that can be used in MRI environments.

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